COVID-19 and Kawasaki Disease: Novel Virus and Novel Case.

  title={COVID-19 and Kawasaki Disease: Novel Virus and Novel Case.},
  author={Veena G. Jones and Marcos Mills and D Su{\'a}rez and Catherine A. Hogan and Debra M. Yeh and J Bradley Segal and Elizabeth L. Nguyen and Gabrielle R Barsh and Shiraz A Maskatia and Roshni Mathew},
  journal={Hospital pediatrics},
In the midst of the coronavirus disease 2019 (COVID-19) pandemic, we are seeing widespread disease burden affecting patients of all ages across the globe. However, much remains to be understood as clinicians, epidemiologists, and researchers alike are working to describe and characterize the disease process while caring for patients at the frontlines. We describe the case of a 6-month-old infant admitted and diagnosed with classic Kawasaki disease, who also screened positive for COVID-19 in the… 

Figures from this paper

Discovering Associations: Kawasaki Disease and COVID-19

A case of a 2-year-old female who presented with symptoms of prolonged fever, conjunctivitis, extremity edema, rash, dry/cracked lips, fussiness and fatigue, and a notable absence of respiratory symptoms is described, showing an association between Kawasaki Disease and SARS-CoV-2 virus.

Kawasaki-like disease in children with COVID-19

Investigation of children with typical and atypical Kawasaki disease (KD) likely to be associated with COVID-19 found clinical features were consistent with incomplete KD in three patients, and pediatricians need to be aware of such atypicals presentations resembling KD for early diagnosis of CO VID-19.

A Case Report of Pediatric Kawasaki Disease and COVID-19 Association

There might be a correlation between COVID-19 infection and hyperinflammatory conditions, like Kawasaki disease, especially in pediatrics presenting with inflammatory symptoms, according to this case report.

COVID-19 in Pediatric Patients: A Focus on CHD Patients

COVID-19 course of illness in pediatric population is discussed with a special emphasis on the cardiac manifestations of the disease in healthy population and also on the disease course in congenital heart disease patients in particular.

Coronavirus Disease (COVID-19): Comprehensive Review of Clinical Presentation

The extensive literature available on COVID-19 about various clinical presentations based on the organ system involved as well as clinical presentation in specific population including children, pregnant women, and immunocompromised patients are reviewed.

Covid-19 and Kawasaki Disease: A Glimpse at the Past for a Predictable Future

The term “Covid-19-associated vasculitis” is thought to be a much more appropriate term for this disease, rather than ”C Covid- 19-associated KD”, since the two similar but distinct entities may even coexist since the “true” KD has the highest incidence in March–April.

Fever with Rash is One of the First Presentations of COVID-19 in Children: A Case Report

As a different manifestation of SARS-CoV-2, infected children may initially present fever and rash, which is considered as a consequence of the hyperinflammatory response or direct effect of the virus.

Kawasaki Disease-Like Features in 10 Pediatric COVID-19 Cases: A Retrospective Study

Children with coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), usually present with symptoms of mild upper respiratory tract

Febrile Morbilliform Rash as a Clinical Presentation of COVID-19 in a Pediatric Patient

The case of a previously healthy 16-month-old boy who presented with a three-day history of febrile morbilliform exanthematous rash associated with confirmed COVID-19 infection is described to expand the knowledge base with respect to the diverse presentations of this highly contagious illness, particularly among pediatric patients.

Coronavirus-2019 Disease (COVID-19) in Children

  • F. Ovalı
  • Medicine
    Medeniyet medical journal
  • 2020
COVID-19 disease affects all ages, but severe cases of the disease and mortality are very rarely seen among children, and there is no evidence for transmission through breastmilk; therefore infected mothers should breastfeed their infants by taking all precautions.



Implications of COVID-19 in pediatric rheumatology

In this review, a systematic literature search was conducted utilizing MEDLINE/PubMed and Scopus databases, and 231 COVID-19 patients with rheumatic diseases have been identified, and only one of these patients was a child.

Concurrent Respiratory Viruses and Kawasaki Disease

A positive respiratory viral PCR or presence of respiratory symptoms at the time of presentation should not be used to exclude a diagnosis of Kawasaki disease, and no differences in clinical presentations or outcomes in children with KD stratified according to positive or negative respiratory viral DNA testing were observed.

Epidemiological Characteristics of 2143 Pediatric Patients With 2019 Coronavirus Disease in China.

Although clinical manifestations of children’s COVID-19 cases were generally less severe than those of adults’ patients, young children, particularly infants, were vulnerable to infection and this study provides strong evidence for human-to-human transmission.

The Epidemiology and Pathogenesis of Kawasaki Disease

It is proposed an unidentified (“new”) RNA virus infects bronchial epithelium usually causing asymptomatic infection but KD in a subset of genetically predisposed children, resulting in increasing immunity with age and with transplacental immunity, as with some classic viruses.

Detection rate and clinical impact of respiratory viruses in children with Kawasaki disease

A positive RT-PCR for currently epidemic respiratory viruses should not be used as an evidence against the diagnosis of Kawasaki disease, as these viruses were not associated with the incomplete presentation of KD and coronary artery dilatation.

Cardiac MRI of Children with Multisystem Inflammatory Syndrome (MIS-C) Associated with COVID-19: Case Series

Cardiac MRI findings favor post-infectious myocarditis in children and adolescents with COVID-19.

Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association

These recommendations provide updated and best evidence-based guidance to healthcare providers who diagnose and manage Kawasaki disease, but clinical decision making should be individualized to specific patient circumstances.

Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR

  • V. CormanO. Landt C. Drosten
  • Medicine, Biology
    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
  • 2020
A validated diagnostic workflow for 2019-nCoV is presented, its design relying on close genetic relatedness of 2019- nCoV with SARS coronavirus, making use of synthetic nucleic acid technology.


It was shown that 8.8% of patients with KD had documented respiratory viral infections and patients with concomitant viral infections had a higher frequency of coronary artery dilatations and were significantly more often diagnosed with incomplete KD.