COVID-19 and Kawasaki Disease: Finding the Signal in the Noise.

  title={COVID-19 and Kawasaki Disease: Finding the Signal in the Noise.},
  author={Alan R. Schroeder and Karen M. Wilson and Shawn L. Ralston},
  journal={Hospital pediatrics},
On April 7, 2020, Hospital Pediatrics published a case report describing an infant who was diagnosed with and treated for Kawasaki disease (KD) and also happened to test positive for severe acute respiratory syndrome coronavirus 2, the causative agent of coronavirus disease (COVID-19).1 Before this publication, we had been reading multiple reports of vascular and multisystem inflammatory involvement in adult patients with COVID-19. Although our journal does not traditionally publish case… 

COVID-19 in Children: An Ample Review

  • I. Ciuca
  • Medicine, Psychology
    Risk management and healthcare policy
  • 2020
It is highlighted that COVID-19 in children is similar to the disease in the adult population, but with particularities regarding clinical manifestations, laboratory test results, chest imaging, and treatment, and the prognosis is much better for children compared to adults.

Kawasaki and COVID-19 disease in children: a systematic review.

A significant increase in the incidence of Kawasaki-type diseases after the onset of the epidemic has been reported, suggesting an association between the COVID-19 epidemic and the high incidence of a severe form of KD.

Similarities and Differences Between COVID-19-Related Multisystem Inflammatory Syndrome in Children and Kawasaki Disease

A narrative review is to discuss the differences between MIS-C and KD with the aim of increasing pediatricians' awareness of this new condition and guide them in the process of differential diagnosis.

COVID-19 and the young heart: what are we missing?

Because the number of children with cardiac manifestations of COVID-19 is likely small at any one institution, it may be beneficial to focus attention on collaborative, multicenter studies to help determine the most successful treatment options, as well as the longitudinal outcomes for these patients.

RMHP_A_257180 661..669

It is highlighted that COVID-19 in children is similar to the disease in the adult population, but with particularities regarding clinical manifestations, laboratory test results, chest imaging, and treatment, and the prognosis is much better for children compared to adults.

Enfermedad de Kawasaki asociada a COVID-19: Revisión Sistemática

Although the studies carried out indicate that there may be a relationship between Kawasaki syndrome and COVID 19, it cannot be assured that it is a complication due to a reaction of the immune system of children.

Clinical characteristics of 10 children with a pediatric inflammatory multisystem syndrome associated with COVID-19 in Iran

Children with COVID-19 may present symptoms similar to Kawasaki disease and inflammatory syndromes and PIMS should be considered in children with fever, rash, seizure, cough, tachypnea, and gastrointestinal symptoms such as vomiting, diarrhea, and abdominal pain.

Murine Typhus in 5 Children Hospitalized for Multisystem Inflammatory Syndrome in Children.

Clinical and laboratory characteristics of these children are presented to illustrate similarities to MIS-C, which can also be shared with viral, bacterial, or other regional endemic infections, as well as noninfectious inflammatory diseases.



COVID-19 and Kawasaki Disease: Novel Virus and Novel Case.

This paper describes the case of a 6-month-old infant admitted and diagnosed with classic Kawasaki disease, who also screened positive for COVID-19 in the setting of fever and minimal respiratory symptoms, and the indications for CO VID-19 testing in the febrile infant.

Epidemiology of COVID-19 Among Children in China

The distribution of children’s COVID-19 cases varied with time and space, and most of the cases were concentrated in Hubei province and surrounding areas, providing strong evidence of human-to-human transmission.

Epidemiological Characteristics of 2143 Pediatric Patients With 2019 Coronavirus Disease in China.

Although clinical manifestations of children’s COVID-19 cases were generally less severe than those of adults’ patients, young children, particularly infants, were vulnerable to infection and this study provides strong evidence for human-to-human transmission.

SARS-CoV-2 infection in children

In order to prevent transmission of SARS-CoV-2, hygienic rules should be pursued in the community, social distancing should be observed, and the family members and contacts of patients who have been diagnosed should be screened and isolated.

Coronavirus Disease 2019 in Children — United States, February 12–April 2, 2020

Data support previous findings that children with COVID-19 might not have reported fever or cough as often as do adults and social distancing and everyday preventive behaviors remain important for all age groups as patients with less serious illness and those without symptoms likely play an important role in disease transmission.

Children with Covid-19 in Pediatric Emergency Departments in Italy

This letter describes a cohort of 100 children younger than 18 years of age with RT-PCR–confirmed Covid-19 who were assessed in 17 pediatric emergency departments in Italy.

SARS-CoV-2 Infection in Children

Investigators in Wuhan, China, describe the spectrum of Covid-19 illness in children under the age of 16 years in SARS-CoV-2 Infection in Children.

Evidence based medicine: what it is and what it isn't

As evidence based medicine continues to evolve and adapt, now is a useful time to refine the discussion of what it is andWhat it is not.

Delayed Diagnosis of Kawasaki Syndrome: An Analysis of the Problem

Because coronary artery aneurysms occurred significantly more often in the patients in the DDG, more education is needed to teach health care providers to have a high index of suspicion for KS in young children presenting with fever/rash illnesses.