COVID-19 RNA Based Vaccines and the Risk of Prion Disease

  title={COVID-19 RNA Based Vaccines and the Risk of Prion Disease},
  author={J. Bart Classen},
Development of new vaccine technology has been plagued with problems in the past. The current RNA based SARSCoV-2 vaccines were approved in the US using an emergency order without extensive long term safety testing. In this paper the Pfizer COVID-19 vaccine was evaluated for the potential to induce prion-based disease in vaccine recipients. The RNA sequence of the vaccine as well as the spike protein target interaction were analyzed for the potential to convert intracellular RNA binding… 

Review of COVID-19 Vaccines and the Risk of Chronic Adverse Events Including Neurological Degeneration

Many of the potential long-term risks that could result from receiving one of the COVID-19 vaccines are reviewed, including the potential for the spike protein and its mRNA to cause prion disease and reasons why the vaccine could be much more dangerous than the natural infection.

COVID-19 Vaccine Associated Parkinson's Disease, A Prion Disease Signal in the UK Yellow Card Adverse Event Database

  • J. Classen
  • Medicine, Biology
    Journal of Medical – Clinical Research & Reviews
  • 2021
The findings suggest that regulatory approval for COVID vaccines was premature and that widespread use should be halted until full long term safety studies evaluating prion toxicity has been complete, and alternatives like the Measles Mumps Rubella (MMR) vaccine should be explored for those desiring immunization against COVID-19.

Maternal COVID-19 Vaccination and Its Potential Impact on Fetal and Neonatal Development

This review has explored components of the first-generation viral vector and mRNA COVID-19 vaccines that are believed to contribute to adverse reactions and which may negatively impact fetal and neonatal development and a discussion of the potential for using an ovine model to explore the long-term outcomes of CO VID-19 vaccination during the prenatal and Neonatal periods.

Expression of Concern: Potential Risks and Unknown Effects of mRNA Vaccines On Population Health

  • Jianqing Wu
  • Political Science
    International Journal of Coronaviruses
  • 2022
The litigation outcome of Rundup caused me to examine the risks of the two mRNA vaccines (Pfizer/BioNTech and Moderna), which are used in the population vaccination campaign in the U.S. I will


  • A. Labidi
  • Medicine, Biology
    International Journal of Advanced Research
  • 2021
This review article presents the organization and the function of the immune system that protects us against diseases, the virology, the infection, the transmission and the pathogenesis of SARS-Cov-2, the disease Covid-19, the development of vaccines against Sars-C Cov-2 and some of the questions raised by these vaccines, as well as suggested responses to them.

Are the mRNA vaccines inducing the Sanarelli-Shwartzman phenomenon?

Under the ensemble HCC hypothesis, it is proposed that inflammatory stress and scurvy promote loss of chirality control, anomeric fidelity, phenotypic stability, and immune function, both humoral and cell-mediated, with the dialyzable transfer factor, L-ascorbic acid, and spin water playing central roles.

Coronavirus disease 2019 (Covid‐19) vaccination recommendations in special populations and patients with existing comorbidities

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Implementing proactive preventive lifestyle changes must begin now, starting with simple, safe, and inexpensive dietary modifications that can quickly lead to a healthier population.

International Journal of Education Humanities and Social Science

Government and societies are urged to sponsor studies to understand how mRNA vaccines damage liver and brain, what could be done to mitigate future adverse impacts and how to prevent humanity disasters like this from happening again.

Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity

SARS-CoV-2 Prion-Like Domains in Spike Proteins Enables Higher Affinity to ACE2

The present findings indicate that the identified PrDs in the SARS-CoV-2 receptor-binding domain (RBD) and ACE2 region that interacts with RBD have important functional roles in viral adhesion and entry.

Diverse Functional Autoantibodies in Patients with COVID-19

It is established that these autoantibodies perturb immune function and impair virological control by inhibiting immunoreceptor signaling and by altering peripheral immune cell composition, and found that murine surrogates of these autoantsibodies exacerbate disease severity in a mouse model of SARS-CoV-2 infection.

Structural basis of receptor recognition by SARS-CoV-2

This study determines the crystal structure of the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2 (engineered to facilitate crystallization) in complex with ACE2 and sheds light on the structural features that increase its binding affinity to ACE2.

The crystal structure of TDP-43 RRM1-DNA complex reveals the specific recognition for UG- and TG-rich nucleic acids

A model is suggested showing that the two RRMs in each protomer of TDP-43 homodimer work together in RNA binding and thus the dimeric T DP-43 recognizes long clusters of UG-rich RNA to achieve high affinity and specificity.

Zinc binding to RNA recognition motif of TDP-43 induces the formation of amyloid-like aggregates

It is shown that zinc binds to this TDP-43 domain with a dissociation constant in the micromolar range and modifies its tertiary structure leading to a decrease of its thermostability and thioflavin-T-positive structures allowing to hypothesize the direct implication of zinc ions in pathological aggregation of T DP-43.

Characterising the RNA targets and position-dependent splicing regulation by TDP-43; implications for neurodegenerative diseases

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Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses

The RNA targets of TAF15 are characterized and points of convergence and divergence between the targets ofTAF15, FUS and TDP43 in several neuronal systems are identified in several neuron systems to reveal convergent and divergent roles for FUS, T AF15 and T DP43 in RNA metabolism.

FUS Recognizes G Quadruplex Structures Within Neuronal mRNAs

Native gel electrophoresis and steady-state fluorescence spectroscopy are used to demonstrate specific nanomolar binding of the FUS C-terminal RGG box and of full-length FUS to the RNA G quadruplex structures formed in the 3′-UTR of PSD-95 and Shank1a mRNAs.