COVID-19 Aerosolized Viral Loads, Environment, Ventilation, Masks, Exposure Time, Severity, And Immune Response: A Pragmatic Guide Of Estimates

  title={COVID-19 Aerosolized Viral Loads, Environment, Ventilation, Masks, Exposure Time, Severity, And Immune Response: A Pragmatic Guide Of Estimates},
  author={Epperly De and Rinehart Kr and Caney Dn},
Abstract It can be shown that over 94% of COVID-19 superspreading events occurred in limited ventilation areas suggesting aerosolized transmission is a strong contributor to COVID-19 infections. This study helps answer “How long may a person safely remain within various environments?” And “What exposure levels could result in immunity without becoming ill via asymptomatic graduated inoculation?” COVID-19 infection likelihood, symptom severity, and immune response dependencies include viral load… 
1 Citations

Tables from this paper

Repeated Exposure to Subinfectious Doses of SARS-CoV-2 May Promote T Cell Immunity and Protection against Severe COVID-19

It is hypothesized that an immune defence against severe COVID-19, provided by SARS-CoV-2-specific T cells progressively developing upon natural exposure to low virus doses present in populated environments, is provided, and non-pharmaceutical interventions would play a double role.



Airborne Transmission of SARS-CoV-2: Theoretical Considerations and Available Evidence.

The coronavirus disease 2019 (COVID-19) pandemic has reawakened the long-standing debate about the extent to which common respiratory viruses are transmitted via respiratory droplets vs aerosols, and whether droplets or aerosols predominate in the transmission of SARS-CoV-2 has critical implications.

Role of air changes per hour (ACH) in possible transmission of airborne infections

It is shown that moving away from the patient generally reduces the infection risk in a transient (coughing) situation, although the effect is more pronounced under higher flow rate, and that the ventilation system design may be a more important factor than flow rate.

Influenza Virus Aerosols in Human Exhaled Breath: Particle Size, Culturability, and Effect of Surgical Masks

The abundance of viral copies in fine particle aerosols and evidence for their infectiousness suggests an important role in seasonal influenza transmission.

What settings have been linked to SARS-CoV-2 transmission clusters?

The aim of this work was to inform such exit strategies by exploring the types of indoor and outdoor settings where transmission of SARS-CoV-2 has been reported to occur and result in clusters of cases, and identifying potential settings that result in transmission clusters.

Viable SARS-CoV-2 in the air of a hospital room with COVID-19 patients

Patients with respiratory manifestations of COVID-19 produce aerosols in the absence of aerosol-generating procedures that contain viable SARS-CoV-2, and these aerosols may serve as a source of transmission of the virus.

Functional SARS-CoV-2-specific immune memory persists after mild COVID-19

It is demonstrated that mild COVID-19 elicits memory lymphocytes that persist and display functional hallmarks associated with antiviral protective immunity.

Neutralizing antibodies correlate with protection from SARS-CoV-2 in humans during a fishery vessel outbreak with high attack rate

The development of vaccines against SARS-CoV-2 would be greatly facilitated by the identification of immunological correlates of protection in humans, and the presence of neutralizing antibodies from prior infection was significantly associated with protection against re-infection.

Transmission of SARS-CoV 2 During Long-Haul Flight

In-flight transmission that probably originated from 1 symptomatic passenger caused a large cluster of cases during a long flight and guidelines for preventing SARS-CoV-2 infection among air passengers should consider individual passengers’ risk for infection, the number of passengers traveling, and flight duration.

Probable Evidence of Fecal Aerosol Transmission of SARS-CoV-2 in a High-Rise Building

This study investigated whether SARS-CoV-2 transmission via fecal aerosols in the drainage pipe system may have been the cause of COVID-19 infection in a cluster of 3 families living in a high-rise building in China.

A Dose Finding Study of a Wild-Type Influenza A/H3N2 virus in a Healthy Volunteer Human Challenge Model.

The A/Bethesda/MM1/H3N2 challenge virus safely induced MMID in healthy volunteers, but caused less MMID than the A(H1N1)pdm09 challenge virus even at the highest dose, indicating that preexisting immunity factors other than anti-HA antibody may limit shedding inhealthy volunteers.