COVID-19 2022 update: transition of the pandemic to the endemic phase

  title={COVID-19 2022 update: transition of the pandemic to the endemic phase},
  author={Michela Biancolella and Vito Luigi Colona and Ruty Mehrian-Shai and Jessica Watt and Lucio Luzzatto and Giuseppe Novelli and Juergen K. V. Reichardt},
  journal={Human Genomics},
COVID-19, which is caused by the SARS-CoV-2, has ravaged the world for the past 2 years. Here, we review the current state of research into the disease with focus on its history, human genetics and genomics and the transition from the pandemic to the endemic phase. We are particularly concerned by the lack of solid information from the initial phases of the pandemic that highlighted the necessity for better preparation to face similar future threats. On the other hand, we are gratified by the… 
Booster Doses of Anti COVID-19 Vaccines: An Overview of Implementation Policies among OECD and EU Countries
Despite diversities related to the differences in health systems, economical resources, and population numbers, and the need to adapt all these factors to a massive vaccination campaign, a progressive convergence towards the same vaccination policies was highlighted.
COVID 19 — Some lessons and many more to learn


COVID-19 one year into the pandemic: from genetics and genomics to therapy, vaccination, and policy
The current state at the milestone of 1 year into the pandemic, as declared by the WHO, is reviewed, focusing first on two major topics: viral variants and the human genetic susceptibility to disease severity.
Progress of the COVID-19 vaccine effort: viruses, vaccines and variants versus efficacy, effectiveness and escape
A snapshot of ongoing vaccine efficacy studies, as well as real-world data on vaccine effectiveness and the impact of virus variants of concern are provided.
COVID-19 Mechanisms in the Human Body—What We Know So Far
The progress made since the commencement of the pandemic regarding the knowledge on COVID-19 mechanisms in the human body, including virus–host interactions, pulmonary and other systemic manifestations, immunological dysregulations, complications, host-specific vulnerability, and long-term health consequences in the survivors are narrated.
Human genetic factors associated with susceptibility to SARS-CoV-2 infection and COVID-19 disease severity
Determinants of differing severity of COVID-19 predominantly include components of the immune response to the virus, while determinant of differing susceptibility to SARS-CoV-2 mostly entail genes related to the initial stages of infection.
WHO Declares COVID-19 a Pandemic
The Director-General of the World Health Organization, Dr. Tedros Adhanom Ghebreyesus, noted that over the past 2 weeks, the number of cases outside China increased 13-fold and theNumber of countries with cases increased threefold, and further increases are expected.
Mapping the human genetic architecture of COVID-19
GWAS meta-analysis of up to 125,584 cases and over 2.5 million controls across 60 studies from 25 countries reveals compelling insights regarding disease susceptibility and severity.
An Update on the Status of Vaccine Development for SARS-CoV-2 Including Variants. Practical Considerations for COVID-19 Special Populations
  • Bulent Kantarcioglu, O. Iqbal, J. Fareed
  • Biology, Medicine
    Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
  • 2022
An updated account of currently available vaccines and those in advanced development with reference to their composition and mechanisms of action is provided and a discussion on the use of vaccines in special populations including immunocompromised patients, pregnant women and other specialized populations are also included.
Cryptic transmission of SARS-CoV-2 and the first COVID-19 wave
A global metapopulation epidemic model is used to provide a mechanistic understanding of the early dispersal of infections and the temporal windows of the introduction of SARS-CoV-2 and onset of local transmission in Europe and the USA and highlights international travel as the key driver.