COUP-TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK/ERK, AKT, and beta-catenin signaling.

@article{Faedo2008COUPTFICC,
  title={COUP-TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK/ERK, AKT, and beta-catenin signaling.},
  author={Andrea Faedo and Giulio Srubek Tomassy and Youlin Ruan and Hannah M Teichmann and Stefan Krauss and Samuel J Pleasure and Sophia Y. Tsai and Ming-jer Tsai and Mich{\`e}le Studer and John L. R. Rubenstein},
  journal={Cerebral cortex},
  year={2008},
  volume={18 9},
  pages={
          2117-31
        }
}
A major unsolved question in cortical development is how proliferation, neurogenesis, regional growth, regional identity, and laminar fate specification are coordinated. Here we provide evidence, using loss-of-function and gain-of-function manipulations, that the COUP-TFI orphan nuclear receptor promotes ventral cortical fate, promotes cell cycle exit and neural differentiation, regulates the balance of early- and late-born neurons, and regulates the balanced production of different types of… CONTINUE READING
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