COUP-TF1 antagonizes Nkx2.5-mediated activation of the calreticulin gene during cardiac development.

@article{Guo2001COUPTF1AN,
  title={COUP-TF1 antagonizes Nkx2.5-mediated activation of the calreticulin gene during cardiac development.},
  author={Lei Guo and Jeffery Lynch and Kimitoshi Nakamura and Larry Fliegel and Hironori Kasahara and Seigo Izumo and Issei Komuro and Luis B. Agellon and Marek Michalak},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 4},
  pages={2797-801}
}
Calreticulin, a Ca(2+) binding chaperone of the endoplasmic reticulum, is also highly expressed in the embryonic heart, and knockout of the calreticulin gene is lethal during embryogenesis because of impaired cardiac development. The protein is down-regulated after birth, and elevated expression of calreticulin in newborn hearts is associated with severe cardiac pathology and death. Here we show that the transcription factor Nkx2.5 activates expression of the calreticulin gene in the heart… CONTINUE READING

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Genes Dev . 11 , 1925 – 1937 Regulation of Calreticulin Gene 2801

J. Prud’homme, A. Arabian, S. Dedhar, R. St-Arnaud
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