COTI-2, a novel small molecule that is active against multiple human cancer cell lines in vitro and in vivo

@inproceedings{Salim2016COTI2AN,
  title={COTI-2, a novel small molecule that is active against multiple human cancer cell lines in vitro and in vivo},
  author={Kowthar Y. Salim and Saman Maleki Vareki and Wayne R. Danter and James Koropatnick},
  booktitle={Oncotarget},
  year={2016}
}
Identification of novel anti-cancer compounds with high efficacy and low toxicity is critical in drug development. High-throughput screening and other such strategies are generally resource-intensive. Therefore, in silico computer-aided drug design has gained rapid acceptance and popularity. We employed our proprietary computational platform (CHEMSAS®), which uses a unique combination of traditional and modern pharmacology principles, statistical modeling, medicinal chemistry, and machine… CONTINUE READING
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