COStar: a D-star Lite-based dynamic search algorithm for codon optimization.

Abstract

Codon optimized genes have two major advantages: they simplify de novo gene synthesis and increase the expression level in target hosts. Often they achieve this by altering codon usage in a given gene. Codon optimization is complex because it usually needs to achieve multiple opposing goals. In practice, finding an optimal sequence from the massive number… (More)
DOI: 10.1016/j.jtbi.2013.11.022

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