CORM-3, a carbon monoxide-releasing molecule, alters the inflammatory response and reduces brain damage in a rat model of hemorrhagic stroke.

@article{Yabluchanskiy2012CORM3AC,
  title={CORM-3, a carbon monoxide-releasing molecule, alters the inflammatory response and reduces brain damage in a rat model of hemorrhagic stroke.},
  author={Andriy Yabluchanskiy and Philip Sawle and Shervanthi Homer-Vanniasinkam and Colin J. Green and R. Foresti and Roberto Motterlini},
  journal={Critical care medicine},
  year={2012},
  volume={40 2},
  pages={544-52}
}
OBJECTIVE Intracerebral hemorrhage is accompanied by a pronounced inflammatory response that mediates brain damage but is also essential for the tissue reparative process. We assessed the effect of CORM-3, a water-soluble carbon monoxide-releasing molecule possessing anti-inflammatory properties, on inflammation and brain injury after intracerebral hemorrhage. DESIGN In vivo and in vitro laboratory study. SETTING Research laboratory. SUBJECTS Male Sprague-Dawley rats, 250-350 g… CONTINUE READING
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