COR pulmonale is caused by monocrotaline and dehydromonocrotaline, but not by glutathione or cysteine conjugates of dihydropyrrolizine.

@article{Pan1993CORPI,
  title={COR pulmonale is caused by monocrotaline and dehydromonocrotaline, but not by glutathione or cysteine conjugates of dihydropyrrolizine.},
  author={Lydia C. Pan and Dennis W. Wilson and Michael W. Lam{\'e} and A. Daniel Jones and Henry J Segall},
  journal={Toxicology and applied pharmacology},
  year={1993},
  volume={118 1},
  pages={87-97}
}
Monocrotaline (MCT) produces pulmonary hypertension and right ventricular hypertrophy in rats. It is generally believed that MCT must undergo hepatic metabolism to reactive metabolites that are subsequently transported to the lungs to induce a pneumotoxic response. Several studies suggest that dehydromonocrotaline (MCTP) is the reactive intermediate that initiates pulmonary toxicity. We recently identified two other MCT metabolites, the glutathione and N-acetylcysteine conjugates of 6,7-dihydro… CONTINUE READING