COQ9, a new gene required for the biosynthesis of coenzyme Q in Saccharomyces cerevisiae.

@article{Johnson2005COQ9AN,
  title={COQ9, a new gene required for the biosynthesis of coenzyme Q in Saccharomyces cerevisiae.},
  author={AnneM. Johnson and Peter M. W. Gin and B. Noelle Marbois and Edward J. Hsieh and Meiying Wu and Mario H Barros and Catherine F. Clarke and Alexander Tzagoloff},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 36},
  pages={
          31397-404
        }
}
Currently, eight genes are known to be involved in coenzyme Q6 biosynthesis in Saccharomyces cerevisiae. Here, we report a new gene designated COQ9 that is also required for the biosynthesis of this lipoid quinone. The respiratory-deficient pet mutant C92 was found to be deficient in coenzyme Q and to have low mitochondrial NADH-cytochrome c reductase activity, which could be restored by addition of coenzyme Q2. The mutant was used to clone COQ9, corresponding to reading frame YLR201c on… CONTINUE READING
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