COPII machinery cooperates with ER-localized Hsp40 to sequester misfolded membrane proteins into ER-associated compartments

Abstract

Proteins that fail to fold in the endoplasmic reticulum (ER) are subjected to ER-associated degradation (ERAD). Certain transmembrane ERAD substrates are segregated into specialized ER subdomains, termed ER-associated compartments (ERACs), before targeting to ubiquitin-proteasome degradation. The traffic-independent function of several proteins involved in… (More)
DOI: 10.1091/mbc.E12-08-0639

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@inproceedings{Kakoi2013COPIIMC, title={COPII machinery cooperates with ER-localized Hsp40 to sequester misfolded membrane proteins into ER-associated compartments}, author={Shogo Kakoi and Tomohiro Yorimitsu and Ken Sato}, booktitle={Molecular biology of the cell}, year={2013} }