COPII machinery cooperates with ER-localized Hsp40 to sequester misfolded membrane proteins into ER-associated compartments

@article{Kakoi2013COPIIMC,
  title={COPII machinery cooperates with ER-localized Hsp40 to sequester misfolded membrane proteins into ER-associated compartments},
  author={Shogo Kakoi and Tomohiro Yorimitsu and Ken Sato},
  journal={Molecular Biology of the Cell},
  year={2013},
  volume={24},
  pages={633 - 642}
}
  • Shogo Kakoi, Tomohiro Yorimitsu, Ken Sato
  • Published in Molecular biology of the cell 2013
  • Biology, Medicine
  • Molecular Biology of the Cell
  • Proteins that fail to fold in the endoplasmic reticulum (ER) are subjected to ER-associated degradation (ERAD). Certain transmembrane ERAD substrates are segregated into specialized ER subdomains, termed ER-associated compartments (ERACs), before targeting to ubiquitin-proteasome degradation. The traffic-independent function of several proteins involved in COPII-mediated ER-to-Golgi transport have been implicated in the segregation of exogenously expressed human cystic fibrosis transmembrane… CONTINUE READING
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 86 REFERENCES

    The structure of a COPII tubule.

    Cargo loading at the ER