COPI-independent Anterograde Transport: Cargo-selective ER to Golgi Protein Transport in Yeast COPI Mutants

@article{Gaynor1997COPIindependentAT,
  title={COPI-independent Anterograde Transport: Cargo-selective ER to Golgi Protein Transport in Yeast COPI Mutants},
  author={Erin C. Gaynor and Scott D Emr},
  journal={The Journal of Cell Biology},
  year={1997},
  volume={136},
  pages={789 - 802}
}
The coatomer (COPI) complex mediates Golgi to ER recycling of membrane proteins containing a dilysine retrieval motif. However, COPI was initially characterized as an anterograde-acting coat complex. To investigate the direct and primary role(s) of COPI in ER/Golgi transport and in the secretory pathway in general, we used PCR-based mutagenesis to generate new temperature-conditional mutant alleles of one COPI gene in Saccharomyces cerevisiae, SEC21 (gamma-COP). Unexpectedly, all of the new… CONTINUE READING
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