COPI budding within the Golgi stack.

  title={COPI budding within the Golgi stack.},
  author={Vincent Popoff and Frank Adolf and Britta Bruegger and Felix Wieland},
  journal={Cold Spring Harbor perspectives in biology},
  volume={3 11},
The Golgi serves as a hub for intracellular membrane traffic in the eukaryotic cell. Transport within the early secretory pathway, that is within the Golgi and from the Golgi to the endoplasmic reticulum, is mediated by COPI-coated vesicles. The COPI coat shares structural features with the clathrin coat, but differs in the mechanisms of cargo sorting and vesicle formation. The small GTPase Arf1 initiates coating on activation and recruits en bloc the stable heptameric protein complex coatomer… CONTINUE READING


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