COPD is associated with a macrophage scavenger receptor-1 gene sequence variation.

@article{Ohar2010COPDIA,
  title={COPD is associated with a macrophage scavenger receptor-1 gene sequence variation.},
  author={Jill A. Ohar and Raymond F. Hamilton and S{\'i}qun Lilly Zheng and Alireza Sadeghnejad and David A. Sterling and Jianfeng Xu and Deborah A. Meyers and Eugene Bleecker and Andrij Holian},
  journal={Chest},
  year={2010},
  volume={137 5},
  pages={
          1098-107
        }
}
BACKGROUND Macrophages play an important role in COPD. We genotyped at-risk smokers to evaluate the role of polymorphisms in the macrophage scavenger receptor-1 gene (MSR1) in COPD susceptibility and related measures of lung function. Then, in macrophages from donors with specific MSR1 genotypes, we determined the effect of MSR1 single nucleotide polymorphisms (SNPs) on macrophage function by examining in vitro adhesion, receptor expression, and cell number in culture as an index of increased… CONTINUE READING
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