COP9 signalosome subunit 6 binds and inhibits avian leukosis virus integrase.

Abstract

The retroviral integrase plays an essential role in the integration of reverse-transcribed retroviral cDNA into the host cell genome, and serves as an important target for anti-viral therapeutics. In this study, we identified the COP9 signalosome subunit 6 (CSN6) as a novel avian leukosis virus (ALV) integrase binding protein. Co-immunoprecipitation and GST… (More)
DOI: 10.1016/j.bbrc.2014.09.116

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