COOH-terminal disruption of lipoprotein lipase in mice is lethal in homozygotes, but heterozygotes have elevated triglycerides and impaired enzyme activity.

Abstract

The role of the enzyme lipoprotein lipase (LPL) in atherosclerosis is uncertain. To generate an animal model of LPL deficiency, we targeted the LPL gene in embryonic stem cells with a vector designed to disrupt the COOH terminus of the protein and used these cells to generate LPL-deficient mice. Germ line transmission of the disrupted LPL allele was… (More)

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Cite this paper

@article{Coleman1995COOHterminalDO, title={COOH-terminal disruption of lipoprotein lipase in mice is lethal in homozygotes, but heterozygotes have elevated triglycerides and impaired enzyme activity.}, author={Trey Coleman and Richard L. Seip and Jeffrey M. Gimble and Daeho Lee and Naoyuki Maeda and Clay F. Semenkovich}, journal={The Journal of biological chemistry}, year={1995}, volume={270 21}, pages={12518-25} }