COOH-terminal clustering of autoantibody and T-cell determinants on the structure of GAD65 provide insights into the molecular basis of autoreactivity.

@article{Fenalti2008COOHterminalCO,
  title={COOH-terminal clustering of autoantibody and T-cell determinants on the structure of GAD65 provide insights into the molecular basis of autoreactivity.},
  author={Gustavo Fenalti and C S Hampe and Yasir Arafat and Ruby H P Law and J. P. Banga and Ian R. Mackay and James C. Whisstock and Ashley M. Buckle and Merrill J. Rowley},
  journal={Diabetes},
  year={2008},
  volume={57 5},
  pages={
          1293-301
        }
}
OBJECTIVE To gain structural insights into the autoantigenic properties of GAD65 in type 1 diabetes, we analyzed experimental epitope mapping data in the context of the recently determined crystal structures of GAD65 and GAD67, to allow "molecular positioning" of epitope sites for B- and T-cell reactivity. RESEARCH DESIGN AND METHODS Data were assembled from analysis of reported effects of mutagenesis of GAD65 on its reactivity with a panel of 11 human monoclonal antibodies (mAbs… CONTINUE READING

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