CONVULSIONS RELATED TO ENOXACIN

@article{Simpson1985CONVULSIONSRT,
  title={CONVULSIONS RELATED TO ENOXACIN},
  author={K. Simpson and Martin J Brodie},
  journal={The Lancet},
  year={1985},
  volume={326}
}

Topics from this paper

Applicability of hiPSC-Derived Neuronal Cocultures and Rodent Primary Cortical Cultures for In Vitro Seizure Liability Assessment
TLDR
It is indicated that hiPSC-derived neuronal cocultures may outperform rodent primary cortical cultures with respect to detecting seizures, thereby paving the way towards animal-free seizure assessment.
Ubiquitous Nature of Fluoroquinolones: The Oscillation between Antibacterial and Anticancer Activities
TLDR
The extended roles of fluoroquinolones are reviewed and their prospects as lead for the unmet needs of “small and safe” multimodal-targeting drug scaffolds are reviewed.
Drug-drug interaction between ciprofloxacin and diclofenac ophthalmic drops at ocular level
In present times, there has been interest in multi-drug combinations for treatment of ocular infections, which are more commonly antibiotics and analgesics. Ciprofloxacin and diclofenac sodium were
Effect of Enoxacin, Felbinac, and Sparfloxacin on Fatty Acid Metabolism and Glucose Concentrations in Rat Tissues
TLDR
The disturbance of both fatty acid metabolism and glucose levels might be associated with the increased susceptibility to convulsions, which may contribute to further understanding of the toxic effects associated with these drugs.
Hiroyuki Ohta in Rat Tissues Effect of Enoxacin , Felbinac , and Sparfloxacin on Fatty Acid Metabolism and Glucose Concentrations
Multiple changes in metabolic levels could be useful for understanding physiological toxicity. To explore further risk factors for the convulsions induced by the interaction of nonsteroidal
Quinolones of Psychiatric and Neurological Adverse Reactions
TLDR
The aim of this article was to review the neurological and psychiatric adverse drug reaction (ADR) profile of quinolones, using a literature search strategy designed to identify case reports and case series related to quInolone-associated neurological and Psychiatric ADRs.
Quinolones: review of psychiatric and neurological adverse reactions.
TLDR
The aim of this article was to review the neurological and psychiatric adverse drug reaction (ADR) profile of quinolones, using a literature search strategy designed to identify case reports and case series related to quInolone-associated neurological and Psychiatric ADRs.
A Seizure Attributed to Ofloxacine in a Woman Undergoing Detoxification for Alcohol Dependence
TLDR
The present case alerts us to the possibility that seizures may occur in alcohol dependent patients treated with benzodiazepines who concomitantly prescribed a fluoroquinolone, and these widely-used antibiotics should be prescribed with caution to patients undergoing detoxification for alcohol dependence.
Convulsant activity of sitafloxacin and its interactions with anti-inflammatory drugs in mice
  • S. Hori
  • Medicine
    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
  • 2009
TLDR
It is suggested that sitafloxacin has weak convulsal activity and that the convulsant activity of sitfloxACin is not enhanced when it is administered with anti-inflammatory drugs.
...
1
2
3
4
5
...

References

SHOWING 1-6 OF 6 REFERENCES
Serum and sputum concentrations of enoxacin after single oral dosing in a clinical and bacteriological study.
TLDR
Nine of the 15 patients treated with enoxacin by mouth with acute purulent exacerbations of chronic bronchitis had to abandon the treatment due to unwanted drug effects (principally nausea, but some patients had hallucinations, dizziness or epileptiform attacks) possibly related to interference with theophylline metabolism.
The clinical pharmacokinetics and tolerance of enoxacin in healthy volunteers.
TLDR
St steady-state pharmacokinetics were characterized by prompt absorption, first-order elimination, and high urinary concentrations of enoxacin, and the most frequently-reported adverse experiences involved the gastro-intestinal tract, the central nervous system, andThe skin.
In vitro activity of enoxacin, a quinolone carboxylic acid, compared with those of norfloxacin, new beta-lactams, aminoglycosides, and trimethoprim
  • N. Chin, H. Neu
  • Biology, Medicine
    Antimicrobial Agents and Chemotherapy
  • 1983
TLDR
Enoxacin inhibited organisms resistant to cefotaxime, moxalactam, gentamicin, and piperacillin, but serum did not decrease minimal inhibitory concentrations or minimal bactericidal concentrations, and resistance frequency development was less than 10(-9) for most bacterial species.
Convulsions and hyperglycaemia associated with nalidixic acid.
TLDR
An otherwise healthy patient who had convulsions and hyperglycaemia (confirmed by a glucose-specific method4) while on a therapeutic dose of the drug.
CONVULSIONS, HYPERGLYCEMIA, AND GLYCOSURIA FROM OVERDOSE OF NALIDIXIC ACID.
TLDR
NALIDIXIC ACID is an antibacterial agent used in the treatment of urinary-tract infections and may be an effective agent against some of the intractable gram-negative bacteria, including Proteus, Escherichia coli, Aerobacter, and Klebsiella.