CONTRAGESTION WITH RU 486: A NEW APPROACH TO POSTOVULATORY FERTILITY CONTROL

@article{Baulieu1989CONTRAGESTIONWR,
  title={CONTRAGESTION WITH RU 486: A NEW APPROACH TO POSTOVULATORY FERTILITY CONTROL},
  author={Etienne Emile Baulieu},
  journal={Acta Obstetricia et Gynecologica Scandinavica},
  year={1989},
  volume={68}
}
  • E. Baulieu
  • Published 1 January 1989
  • Biology, Medicine
  • Acta Obstetricia et Gynecologica Scandinavica
The steroidal derivative RU 486 (17β‐hydroxy‐11β‐(4‐dimethyl‐aminophenyl)‐17α‐(prop‐1‐ynyl) estra‐4, 9‐dien‐3‐one) is the first potent antiprogestin to be used clinically. RU 486 blocks the action of progesterone by a reversible inhibition of the action of progesterone on its own receptors. This reversibility allows endocrine functions to return quickly to normal after discontinuation of treatment. However, target cells which depend upon a continuity of progesterone action will be irreversibly… 
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TLDR
Available clinical results indicate that RU 486 can be an efficient and safe contragestive agent, especially for the medical termination of early pregnancy, and has significant potential as a post-coital menses inducer or menstrual regulator.
Endometrial and pituitary responses to the steroidal antiprogestin RU 486 in postmenopausal women.
TLDR
It is concluded that, contrary to previous results with experimental animals, the anti-P RU 486 has some progestomimetic activity in humans under specific conditions.
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TLDR
It is suggested that giving a single dose of RU 486 late in the menstrual cycle might be an effective contraceptive strategy and this concept was tested in monkeys.
The progesterone antagonist RU 486. A potential new contraceptive agent
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TLDR
The Demonstration of the Antiprogestin Effects of Ru 486 When Administered To The Human During Hcg-induced Pseudopregnancy is demonstrated.
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TLDR
RU 486, given to normally cycling women at midluteal phase, provokes uterine bleeding and the lack of antiglucocorticosteroid activity, at the dosage of 100 mg/day, suggests that RU 486 may be useful for fertility control.
Pharmacokinetic and Clinical Studies of RU 486 for Fertility Regulation
Previous clinical results indicate that oral administration of RU 486 can be highly effective in terminating very early pregnancy, but that the frequency of incomplete abortion is too high to be
Steroid hormone antagonists at the receptor level: A role for the heat‐shock protein MW 90,000 (hsp 90)
  • E. Baulieu
  • Biology
    Journal of cellular biochemistry
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TLDR
Other antiglucocorticosteroid and antiestrogen systems are reviewed with reference to this hypothesis and a four‐step analysis of the molecular mechanism of antisteroid hormone action at the receptor level is described.
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