CONDITIONING FOR HEMATOPOIETIC TRANSPLANTATION ACTIVATES THE COMPLEMENT CASCADE AND INDUCES A PROTEOLYTIC ENVIRONMENT IN BONE MARROW – A NOVEL ROLE FOR BIOACTIVE LIPIDS AND SOLUBLE C5b-C9 AS HOMING FACTORS

@inproceedings{Kim2012CONDITIONINGFH,
  title={CONDITIONING FOR HEMATOPOIETIC TRANSPLANTATION ACTIVATES THE COMPLEMENT CASCADE AND INDUCES A PROTEOLYTIC ENVIRONMENT IN BONE MARROW – A NOVEL ROLE FOR BIOACTIVE LIPIDS AND SOLUBLE C5b-C9 AS HOMING FACTORS},
  author={Chi Hwa Kim and Wan Wu and Marcin Wysoczynski and Ahmed Abdel-Latif and Manjula Sunkara and Andrew J. Morris and Magdalena J. Kucia and Janina Ratajczak and Mariusz Z Ratajczak},
  booktitle={Leukemia},
  year={2012}
}
We have observed that conditioning for hematopoietic transplantation by lethal irradiation induces a proteolytic microenvironment in the bone marrow (BM) that activates the complement cascade (CC). As a result, BM is enriched for proteolytic enzymes and the soluble form of the terminal product of CC activation, the membrane attack complex C5b-C9 (MAC). At the same time, proteolytic enzymes induced in irradiated BM impair the chemotactic activity of α-chemokine stromal-derived factor-1 (SDF-1… CONTINUE READING

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S1P1 Agonists for Use as Adjunct Mobilizing Agents

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