COMT val158met and 5-HTTLPR Genetic Polymorphisms Moderate Executive Control in Cannabis Users

@article{VerdejoGarca2013COMTVA,
  title={COMT val158met and 5-HTTLPR Genetic Polymorphisms Moderate Executive Control in Cannabis Users},
  author={Antonio Verdejo-Garc{\'i}a and Ana Beatriz Fagundo and A. Calvo Cuenca and Joan Pau Rodr{\'i}guez and Elisabet Cuy{\'a}s and Klaus Langohr and Susana de Sola Llopis and Ester Civit and Mag{\'i} Farr{\'e} and Jordi Pe{\~n}a-Casanova and Rafael de la Torre},
  journal={Neuropsychopharmacology},
  year={2013},
  volume={38},
  pages={1598-1606}
}
The adverse effects of cannabis use on executive functions are still controversial, fostering the need for novel biomarkers able to unveil individual differences in the cognitive impact of cannabis consumption. Two common genetic polymorphisms have been linked to the neuroadaptive impact of Δ9-tetrahydrocannabinol (THC) exposure and to executive functions in animals: the catechol-O-methyltransferase (COMT) gene val158met polymorphism and the SLC6A4 gene 5-HTTLPR polymorphism. We aimed to test… CONTINUE READING
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