COMT val158Met and executive control: a test of the benefit of specific deficits to translational research.

@article{MacDonald2007COMTVA,
  title={COMT val158Met and executive control: a test of the benefit of specific deficits to translational research.},
  author={Angus W. MacDonald and Cameron S. Carter and Janine D. Flory and R. Ferrell and Stephen B. Manuck},
  journal={Journal of abnormal psychology},
  year={2007},
  volume={116 2},
  pages={
          306-12
        }
}
The role of catechol-O-methyltransferase (COMT) val158met in prefrontal cortical deficits associated with the liability to schizophrenia remains controversial. This study evaluated 464 healthy adult participants using three measures of executive functions in working memory: a 3-back version of the N-back continuous performance task (CPT) and two variants of the AX-CPT. The interpretability of N-back performance was confounded by possible generalized deficits, whereas the AX variants included… CONTINUE READING

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