COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome

@article{Gothelf2005COMTGP,
  title={COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome},
  author={Doron Gothelf and Stephan Eliez and Tracy A. Thompson and Christine Hinard and Lauren C Penniman and Carl Feinstein and Hower Kwon and Shuting Jin and Booil Jo and Stylianos E. Antonarakis and Michael A. Morris and Allan L. Reiss},
  journal={Nature Neuroscience},
  year={2005},
  volume={8},
  pages={1500-1502}
}
Although schizophrenia is strongly hereditary, there are limited data regarding biological risk factors and pathophysiological processes. In this longitudinal study of adolescents with 22q11.2 deletion syndrome, we identified the catechol-O-methyltransferase low-activity allele (COMTL) as a risk factor for decline in prefrontal cortical volume and cognition, as well as for the consequent development of psychotic symptoms during adolescence. The 22q11.2 deletion syndrome is a promising model for… CONTINUE READING
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