COMT genotype increases risk for bipolar I disorder and influences neurocognitive performance.

@article{Burdick2007COMTGI,
  title={COMT genotype increases risk for bipolar I disorder and influences neurocognitive performance.},
  author={Katherine E. Burdick and Birgit H Funke and Joseph F Goldberg and John A. Bates and Judith Jaeger and Raju Kucherlapati and Anil K. Malhotra},
  journal={Bipolar disorders},
  year={2007},
  volume={9 4},
  pages={370-6}
}
OBJECTIVES Bipolar disorder (BPD) is an affective disorder characterized by episodes of depression and mania. Cognitive impairment in patients with BPD is common and recent data suggest that it may represent a trait-like feature of the illness, as it persists during periods of wellness and co-segregates in families of bipolar patients. This suggests an underlying genetic predisposition towards cognitive impairment in patients with BPD; however, there have been few studies investigating the… CONTINUE READING

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