COMPARISON OF ORAL 25-HYDROXYCHOLECALCIFEROL, VITAMIN D, AND ULTRAVIOLET LIGHT AS DETERMINANTS OF CIRCULATING 25-HYDROXYVITAMIN D

@article{Stamp1977COMPARISONOO,
  title={COMPARISON OF ORAL 25-HYDROXYCHOLECALCIFEROL, VITAMIN D, AND ULTRAVIOLET LIGHT AS DETERMINANTS OF CIRCULATING 25-HYDROXYVITAMIN D},
  author={T. C. B. Stamp and John G. Haddad and C. A. Twigg},
  journal={The Lancet},
  year={1977},
  volume={309},
  pages={1341-1343}
}
Circulating concentrations of 25-hydroxyvitamin D (25-OHD) were measured during short-term and long-term oral treatment with 25-hydroxycholecalciferol (25-OHD3), 25-H.C.C.) or with vitamin D in over 200 subjects over a period of 5 years. Ten times more vitamin D than 25-OHD3 was required to produce equivalent plasma-25-OHD concentrations. Plasma-25-OHD was a power function of dosage with both compounds. These data indirectly measure the superior therapeutic potency of 25-OHD3, show that dose… 
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TLDR
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  • Medicine
    The American journal of clinical nutrition
  • 1999
TLDR
The assembled data from many vitamin D supplementation studies reveal a curve for vitamin D dose versus serum 25-hydroxyvitamin D [25(OH)D] response that is surprisingly flat up to 250 microg (10000 IU) vitamin D/d.
Vitamin D supplementation , 25-hydroxyvitamin D concentrations , and safety 1 , 2
For adults, the 5-mg (200 IU) vitamin D recommended dietary allowance may prevent osteomalacia in the absence of sunlight, but more is needed to help prevent osteoporosis and secondary
Vitamin D and its Major Metabolites: Serum Levels after Graded Oral Dosing in Healthy Men
TLDR
The quantitative relationships between graded oral dosing with vitamin D3, 25(OH)D3, and 1,25( OH)2D3 for short treatment periods and changes in circulating levels of these substances were determined.
Investigation of the effects of dietary supplementation with 25-hydroxyvitamin D3 and vitamin D3 on indicators of vitamin D status in healthy dogs.
TLDR
Potency of the dietary 25(OH)D3 supplement estimated on the basis of targeted content was 5 times that of vitamin D3 to increase indicators ofitamin D status in the study sample.
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