COMPARISON OF ORAL 25-HYDROXYCHOLECALCIFEROL, VITAMIN D, AND ULTRAVIOLET LIGHT AS DETERMINANTS OF CIRCULATING 25-HYDROXYVITAMIN D

@article{Stamp1977COMPARISONOO,
  title={COMPARISON OF ORAL 25-HYDROXYCHOLECALCIFEROL, VITAMIN D, AND ULTRAVIOLET LIGHT AS DETERMINANTS OF CIRCULATING 25-HYDROXYVITAMIN D},
  author={T. C. B. Stamp and John G. Haddad and C. A. Twigg},
  journal={The Lancet},
  year={1977},
  volume={309},
  pages={1341-1343}
}
Circulating concentrations of 25-hydroxyvitamin D (25-OHD) were measured during short-term and long-term oral treatment with 25-hydroxycholecalciferol (25-OHD3), 25-H.C.C.) or with vitamin D in over 200 subjects over a period of 5 years. Ten times more vitamin D than 25-OHD3 was required to produce equivalent plasma-25-OHD concentrations. Plasma-25-OHD was a power function of dosage with both compounds. These data indirectly measure the superior therapeutic potency of 25-OHD3, show that dose… 
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Supplemental 25-Hydroxycholecalciferol Is More Effective than Cholecalciferol in Raising Serum 25-Hydroxyvitamin D Concentrations in Older Adults.
TLDR
25(OH)D3 is ∼3 times as effective as D3 at raising 25-hydroxyvitamin D serum concentrations and achieving steady state and once supplementation is discontinued, the elimination rate of 25(OH), D3 is faster than D3.
Relative effectiveness of oral 25-hydroxyvitamin D3 and vitamin D3 in raising wintertime serum 25-hydroxyvitamin D in older adults.
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Each microgram of orally consumed 25-hydroxyvitamin D3 was about 5 times more effective in raising serum 25(OH)D in older adults in winter than an equivalent amount of vitamin D3.
Effects of Vitamin D2 and 25-Hydroxyvitamin D2 Supplementation on Plasma Vitamin D Epimeric Metabolites in Adult Cats
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Comparing the effectiveness of vitamin D2 and 25(OH)D2 for increasing feline vitamin D status and the abundant concentrations of epimeric forms ofitamin D metabolites found in circulation suggest that these metabolites should be considered during vitamin D analyses in cats.
Assessment of plasma 25-hydroxyvitamin D response to ultraviolet irradiation over a controlled area in young and elderly subjects.
TLDR
Exposure to ultraviolet irradiation over a small area of dorsal skin led to a rapid rise of plasma 25-(OH)D in most subjects with a subsequent plateau in subjects studied for up to 15 min total exposure, which may indicate that cutaneous synthesis of vitamin D is rapid but limited.
Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2.
TLDR
Although the 1.7-times greater efficacy for vitamin D3 shown here may seem small, it is more than what others have shown for 25(OH)D increases when comparing 2-fold differences in vitamin D 3 dose.
Dose-response effects of supplementation with calcifediol on serum 25-hydroxyvitamin D status and its metabolites: A randomized controlled trial in older adults.
TLDR
Calcifediol supplementation rapidly and safely elevates serum 25(OH)D3 concentrations to improve vitamin D status in older adults to investigate the dose-response effects of supplementation with calcifedio compared to vitamin D3.
Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety.
  • R. Vieth
  • Medicine
    The American journal of clinical nutrition
  • 1999
TLDR
The assembled data from many vitamin D supplementation studies reveal a curve for vitamin D dose versus serum 25-hydroxyvitamin D [25(OH)D] response that is surprisingly flat up to 250 microg (10000 IU) vitamin D/d.
Vitamin D supplementation , 25-hydroxyvitamin D concentrations , and safety 1 , 2
For adults, the 5-mg (200 IU) vitamin D recommended dietary allowance may prevent osteomalacia in the absence of sunlight, but more is needed to help prevent osteoporosis and secondary…
Vitamin D and its Major Metabolites: Serum Levels after Graded Oral Dosing in Healthy Men
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The quantitative relationships between graded oral dosing with vitamin D3, 25(OH)D3, and 1,25( OH)2D3 for short treatment periods and changes in circulating levels of these substances were determined.
Investigation of the effects of dietary supplementation with 25-hydroxyvitamin D3 and vitamin D3 on indicators of vitamin D status in healthy dogs.
TLDR
Potency of the dietary 25(OH)D3 supplement estimated on the basis of targeted content was 5 times that of vitamin D3 to increase indicators ofitamin D status in the study sample.
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References

SHOWING 1-10 OF 14 REFERENCES
Circulating 25-hydroxyvitamin D in man.
TLDR
During long-term constant intake of large amounts of vitamin D, serum 25-OHD concentration correlated well with the dose and might offer a quicker and more facile alternative in the clinical use of antiricketic sterols.
Intestinal absorption of 25-hydroxycholecalciferol.
TLDR
Five out of ten patients had markedly abnormal results, which clearly showed the abnormalities of vitamin-D absorption that can occur after partial gastrectomy, in small-bowel disease, and in biliary dysfunction, and may thus be valuable in establishing the cause of osteomalacia in gastrointestinal disease.
Vitamin D—1973☆☆☆
TLDR
The application of the metabolites of vitamin D to clinical problems has been considered and 1α-(OH)D3, an important analog of 1,25-dihydroxyvitamin D, has been introduced as a potentially important therapeutic compound.
Comparative studies on the 25-hydroxylation of vitamin D 3 and dihydrotachysterol 3 .
TLDR
The results support the idea that the regulation of calciferol-25-hydroxylase activity functions to maintain a low circulating level of 25-hydroxyvitamin D3 in the blood even when large amounts of vitamin D3 are being ingested.
Effect of 25-hydroxycholecalciferol on calcium absorption in chronic renal disease.
TLDR
It is indicated that 25(OH)D3 can improve calcium absorption in the absence of renal tissue suggesting that its conversion to 1,25( OH)2D3 may not be necessary for its effect on the gastrointestinal tract in the uremic patient.
Plasma Levels and Therapeutic Effect of 25-Hydroxycholecalciferol in Epileptic Patients taking Anticonvulsant Drugs
TLDR
Findings provided further evidence that anticonvulsant osteomalacia results from hepatic enzyme induction which, by increasing the metabolism of cholecalciferol to inactive compounds, lowers 25-HCC levels in patients whose dietary vitamin D intake and exposure to sunlight are otherwise adequate.
The apparent vitamin D resistance of chronic renal failure. A study of the physiology of vitamin D in man.
TLDR
Differences in the nutritional state of the different populations may explain the frequency of azotemic rickets and osteomalacia in Europe and Asia, as compared with their reputed infrequency in the United States.
Factors in human vitamin D nutrition and in the production and cure of classical rickets.
  • T. Stamp
  • Medicine
    The Proceedings of the Nutrition Society
  • 1975
TLDR
Plasma levels of 25-OHD are therefore a precise measurement of nutritional status and indicate that, under physiological conditions, vitamin D circulates almost exclusively as its hydroxylated derivatives (Stamp, 1973).
The regulation of rat liver calciferol-25-hydroxylase.
TLDR
Data show the existence of a mechanism which regulates the activity of the rat liver calciferol-25-hydroxylase, and this mechanism is reflected in vivo by a decrease in the rate and extent of appearance of 3H-labeled 25-hydroxyvitamin D3 in the blood and liver following a dose of3H- labels administered to rats pretreated with unlabeled vitamin D3.
25-Hydroxycholecalciferol. A comparative study in deficiency rickets and different types of resistant rickets.
TLDR
The results indicate that (a) 25-hydroxycholecalciferol is highly active in deficiency rickets; (b) a defect in the conversion of vitamin D(3) to its active 25-Hydroxy metabolite is probably not the metabolic defect in any of the different types of Vitamin D-resistant rickets studied.
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