COMPARISON OF NATIVE AND REDUCED AND ALKYLATED HUMAN IV IMMUNE SERUM GLOBULIN (ISG) IN EXPERIMENTAL H. IN FLUENZAE TYPE B INFECTION

@article{Schreiber1984COMPARISONON,
  title={COMPARISON OF NATIVE AND REDUCED AND ALKYLATED HUMAN IV IMMUNE SERUM GLOBULIN (ISG) IN EXPERIMENTAL H. IN FLUENZAE TYPE B INFECTION},
  author={J. Schreiber and V. Barrus and G. Siber},
  journal={Pediatric Research},
  year={1984},
  volume={18},
  pages={285A-285A}
}
  • J. Schreiber, V. Barrus, G. Siber
  • Published 1984
  • Medicine
  • Pediatric Research
  • Reduced and alkylated (RA) ISG for intravenous use contains IgG with disrupted inter-heavy chain disulfide bonds. This change alters Fc function, particularly the ability to fix complement. We compared protective activity of RA and native (N) ISG's in infant rats passively immunized with ISG and then challenged with 103 Hib ip. Both ISG's contained 20,000 ng anti-PRP Ab/ml and were cidal in vitro in the presence of complement. Cidality was blocked by absorption with PRP. Cumulative bacteremia… CONTINUE READING