COMPARATIVE TRIAL OF IMPIRAMINE N‐OXIDE AND IMPRAMINE IN THE TREATMENT OF OUT‐PATIENTS WITH DEPRESSIVE SYNDROMES

@article{Rapp1973COMPARATIVETO,
  title={COMPARATIVE TRIAL OF IMPIRAMINE N‐OXIDE AND IMPRAMINE IN THE TREATMENT OF OUT‐PATIENTS WITH DEPRESSIVE SYNDROMES},
  author={Walter Rapp and Matilda Nor{\'e}n and Frank Pedersen},
  journal={Acta Psychiatrica Scandinavica},
  year={1973},
  volume={49}
}
Within the group of tricyclic antidepressants several drugs are available. Their effect is very similar, the difference being mainly in the side effects. The development of new tricyclic antidepressants which have fewer side effects is still a therapeutic goal. Imipramine N-oxide appears to be a preparation having a good antidepressant effect and few side effects (Haug (1967), Gottfries (1968), Ose (1971), Dencker (1971)), and it seemed motivated, therefore, to compare it double-blind with… 

OBJECTIVE ASSESSMENT OF ANTICHOLINERGIC SIDE EFFECTS OF TRICYCLIC ANTIDEPRESSANTS

The weight-increase among the doxepin patients was remarkable. Unfortunately, we have no data concerning the patient’s habitual weight and we therefore do not know how the weight after treatment

Comparative trial of amitriptyline‐N‐oxide and amitriptyline in the treatment of out‐patients with depressive syndromes

  • W. Rapp
  • Psychology, Medicine
    Acta psychiatrica Scandinavica
  • 1978
TLDR
Both drugs had a good antidepressant effect and the effect upon the various depressive symptoms was equal.

Mode of action and relative value of imipramine and similar drugs in the treatment of nocturnal enuresis

TLDR
It was concluded that the psychopharmacological actions of imipramine and imipramsine-N-oxide appear to be important in their effects on enuresis and many children can be treated successfully and the final cure of enures is hastened by breaking a vicious circle of psychological phenomena.

THE EFFECT OF LITHIUM CARBONATE IN COMBINATION WITH TRICYCLIC ANTIDEPRESSANTS IN ENDOGENOUS DEPRESSION: A double‐blind, multicenter trial

TLDR
Treatment response in the total material did not correlate significantly with diagnosis (e.g., whether unipolar or bipolar affective illness), age or sex, and the heterogeneity of this part of the material might easily have obscured any real difference in treatment outcome.

Investigation of the orthostatic reaction after intravenous administration of imipramine, chlorimipramine, and imipramine‐N‐oxide

TLDR
No systemic changes of heart frequency and blood pressure were found during the infusions in spite of the high dosage of tricyclic antidepressants given in such a short period as 1 hour.

The kinetics of imipramine-N-oxide in man.

TLDR
Rats were given imipramine-N-oxide as single intramuscular injection and then as repeated oral doses during continuous treatment, and samples taken at different times after oral doses showed fairly constant concentrations of imipramsine- N-oxide and desipramines in the brain, whereas the concentration of imIPramine was more fluctuating.

Deletion of the mouse Fmo1 gene results in enhanced pharmacological behavioural responses to imipramine

TLDR
The absence of FMO1-mediated N-oxidation of imipramine results in enhanced central nervous system effects of the drug and may explain the basis of the adverse reactions to the drug seen in some patients.

Metabolic N-Dealkylation and N-Oxidation as Elucidators of the Role of Alkylamino Moieties in Drugs Acting at Various Receptors

TLDR
Two aspects will be examined after surveying the metabolism of representative alkylamino-moieties-containing drugs that act at various receptors: the pharmacologic activities and relevant physicochemical properties (basicity and polarity) of the metabolites with respect to their parent drugs and the role of alKYlamino moieties on the molecular docking of drugs in receptors.

The potential of knockout mouse lines in defining the role of flavin-containing monooxygenases in drug metabolism

TLDR
How the use of mouse lines in which Fmo genes have been deleted can demonstrate the role an FMO plays in the metabolism of a drug, particularly if the drug is subject to metabolism by other enzymes, for example, CYPs, or undergoes retro-reduction is discussed.

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