COMPARATIVE MODELING OF INACTIVE UBIQUITIN THIOESTERASE FAM 105 A AND MOLECULAR DOCKING STUDIES OF SYNTHESIZED BENZIMIDAZOLE DERIVATIVES

@inproceedings{Neelamma2016COMPARATIVEMO,
  title={COMPARATIVE MODELING OF INACTIVE UBIQUITIN THIOESTERASE FAM 105 A AND MOLECULAR DOCKING STUDIES OF SYNTHESIZED BENZIMIDAZOLE DERIVATIVES},
  author={M. Neelamma and Kiran Kumar Chitluri},
  year={2016}
}
In this study, homology modeling and molecular docking studies were performed to explore structural features and binding mechanism of synthesized benzimidazole derivatives as ubiquitin inhibitors. A homology modeling procedure was employed to construct a 3D model of ubiquitin protein by using MODELLER9.15. For this procedure, the X-ray crystal structure of Gumby / fam105b in Complex with linear Di-ubiquitin (PDB ID: 4KSL) at 2.83 Å resolution was used as template. The predicted model was… CONTINUE READING

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