COMMUNICATION Making Easier the β-Lactam Fragmentation via Metal-Assistance: Mechanistic Insight

Abstract

The OsH6(PPr3)2-mediated fragmentation of a 4-(2 pyridyl)-2-azedidinone has been achieved and its mechanism has been investigated by DFT calculations. The addition of the C4-H bond of the substrate to OsH2(PPr3)2 allows the active participation of an osmium lone pair in the B-type β-lactam fragmentation process. This new mechanism makes the N1-C4/C2-C3… (More)

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