COL9A2 allelotypes in intervertebral disc disease.

@article{Wrocklage2000COL9A2AI,
  title={COL9A2 allelotypes in intervertebral disc disease.},
  author={Christian Wrocklage and Hansdetlef Wassmann and W. Paulus},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={279 2},
  pages={398-400}
}
An allelic variation of the COL9A2 gene encoding the alpha(2)-chain of collagen IX has recently been identified as a genetic risk factor for intervertebral disc prolapse, resulting in a tryptophane (Trp) substitution at position 326 of the protein. To enable quick screening of a large population we established a single enzyme (BsmFI) restriction assay which was validated by screening disc tissue samples of 250 patients (age, 47.1 +/- 13.7 years). Positive results were confirmed by nucleotide… CONTINUE READING

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