COL1A1 Sp1 polymorphism associates with bone density in early puberty.

@article{Suuriniemi2006COL1A1SP,
  title={COL1A1 Sp1 polymorphism associates with bone density in early puberty.},
  author={Miia Suuriniemi and Vuokko Kovanen and Anitta Mahonen and Markku Al{\'e}n and Qingju Wang and Arja Lyytik{\"a}inen and Sulin Cheng},
  journal={Bone},
  year={2006},
  volume={39 3},
  pages={
          591-7
        }
}
  • Miia Suuriniemi, Vuokko Kovanen, +4 authors Sulin Cheng
  • Published in Bone 2006
  • Biology, Medicine
  • Optimal acquisition of bone mass in puberty is a key determinant of the lifetime risk of osteoporosis and has a strong genetic basis. We investigated the relationship between the COL1A1 Sp1 polymorphism and BMD in early puberty, and how the genotypes relate to bone size and geometry as well as bone turnover and material properties in 247 10- to 13-year-old girls. Bone properties were measured using DXA, pQCT, and ultrasound. Also, serum P1NP, OC, B-ALP, and TRACP 5b were assessed. Our results… CONTINUE READING

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