COL1A1, ESR1, VDR and TGFB1 polymorphisms and haplotypes in relation to BMD in Spanish postmenopausal women

@article{Bustamante2006COL1A1EV,
  title={COL1A1, ESR1, VDR and TGFB1 polymorphisms and haplotypes in relation to BMD in Spanish postmenopausal women},
  author={Mariona Bustamante and Xavier Nogu{\'e}s and Anna Enjuanes and Roberto Elos{\'u}a and Natalia Garcia-Giralt and Llu{\'i}s P{\'e}rez-Edo and Enrique C{\'a}ceres and Ram{\'o}n Carreras and Leonardo Mellibovsky and Susanne Balcells and Adolfo D{\'i}ez-P{\'e}rez and Daniel Grinberg},
  journal={Osteoporosis International},
  year={2006},
  volume={18},
  pages={235-243}
}
Genetic studies of osteoporosis have focused on analysing single polymorphisms in individual genes – with inconclusive results. An alternative approach may involve haplotypes and gene-gene interactions. The aim of the study was to test the association between the COL1A1, ESR1, VDR and TGFB1 polymorphisms or haplotypes and bone mineral density (BMD) in Spanish postmenopausal women. Sixteen polymorphisms were analysed in 719 postmenopausal women. ANOVA, ANCOVA and Xi2 tests were used to perform… CONTINUE READING

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