author={Brian M. Iacoviello and Gang Wu and Evan Alvarez and Kathryn M Huryk and Katherine A. Collins and James W. Murrough and Dan V. Iosifescu and Dennis S. Charney},
  journal={Depression and Anxiety},
There is an urgent need for more effective treatments for major depressive disorder (MDD). As understanding of the cognitive and affective neuroscience underlying psychiatric disorders expands, so do opportunities to develop interventions that capitalize on the capacity for brain plasticity. Cognitive training is one such strategy. In this article, we report a proof‐of‐concept study of a novel cognitive‐emotional training exercise designed to enhance cognitive control for emotional information… 

Initial Evidence for Brain Plasticity Following a Digital Therapeutic Intervention for Depression

Initial evidence is provided that cognitive–emotional training may be associated with changes in short-term plasticity of brain networks implicated in major depressive disorder and pave the way for the principled design of large clinical and neuroimaging studies.

Neuroscience-Informed Cognitive-Affective Training Interventions for Mood and Anxiety Disorders

Cognitive-affective training interventions could represent a novel method for targeting perseverative thinking and negative affective biases in mood and anxiety disorders through modulation of these abnormally functioning neural networks.

A randomized, controlled pilot trial of the Emotional Faces Memory Task: a digital therapeutic for depression

A study led by Brian Iacoviello, Icahn School of Medicine at Mount Sinai shows that after 6 weeks EFMT reduced both clinician-rated and self-reported measures of MDD symptoms, suggesting that digital therapies that can modulate activation patterns in brain areas affected in neuropsychiatric disorders hold great promise as a novel treatment approach.

Moving Beyond Mood: Is it Time to Recommend Cognitive Training for Depression in Older Adults?

To date, there is a lack of well-controlled studies utilising cognitive training for people with depression, but 13 studies employing computer-based cognitive training programs reveal promising results, particularly for improving memory and mood.

Cognitive Control Therapy as a Depression Treatment: a Review of the Literature

Recent investigations have explored the link between depression and executive function (the ability to process and organise information in order to achieve a goal). The specific aspect of executive


To evaluate antidepressant efficacy in MDD patients with cognitive dysfunction, a standardized cognitive battery for use in clinical trials is essential and a representative sample of cognitive assessment tools currently available to assess cognitive function in depressed patients are summarized.

Psychosocial Dysfunction in Major Depressive Disorder—Rationale, Design, and Characteristics of the Cognitive and Emotional Recovery Training Program for Depression (CERT-D)

It is expected that personalizing treatment by participants’ baseline functioning will enhance clinical efficacy, by comparison with standard treatment in which baseline functioning is not considered.



Neurobehavioral Therapies in the 21st Century: Summary of an Emerging Field and an Extended Example of Cognitive Control Training for Depression

The promise of a new generation of therapies targeted to address neurobiological mechanisms thought to underlie psychological disorders, particularly depression, using cognitive and behavioral

Dysfunction in the neural circuitry of emotional self-regulation in major depressive disorder

The results suggest that emotional dysregulation in major depressive disorder is related to a disturbance in the neural circuitry of emotional self-regulation.

Neuroimaging and Depression

An overview of neuroimaging research that has assessed the structure and functioning of the amygdala, subgenual anterior cingulate cortex, and dorsolateral prefrontal cortex in major depression suggests heightened activity in limbic structures that underlie the experience and expression of emotion dampens activation in dorsal cortical structures that are involved in affect regulation.

Cognitive Training for Impaired Neural Systems in Neuropsychiatric Illness

A systems neuroscience rationale for successful cognitive training for neuropsychiatric illnesses is presented, one that emphasizes the distributed nature of neural assemblies that support cognitive and affective processing, as well as their plasticity.

Amelioration of Cognitive Control in Depression by Transcranial Direct Current Stimulation

Neural mechanisms of the cognitive model of depression

The functional and structural neurobiological architecture of Beck's cognitive model of depression is identified and it is shown that in general the negative cognitive biases in depression are facilitated by increased influence from subcortical emotion processing regions combined with attenuated top-down cognitive control.