COBRAme: A computational framework for genome-scale models of metabolism and gene expression

  title={COBRAme: A computational framework for genome-scale models of metabolism and gene expression},
  author={Colton J. Lloyd and Ali Ebrahim and Laurence Yang and Zachary A. King and Edward Catoiu and Edward J. O'Brien and Joanne K. Liu and Bernhard O. Palsson},
  journal={PLoS Computational Biology},
Genome-scale models of metabolism and macromolecular expression (ME-models) explicitly compute the optimal proteome composition of a growing cell. ME-models expand upon the well-established genome-scale models of metabolism (M-models), and they enable new and exciting insights that are fundamental to understanding the basis of cellular growth. ME-models have increased predictive capabilities and accuracy due to their inclusion of the biosynthetic costs for the machinery of life, but they come… 

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