CO2 permeability and bicarbonate transport in microperfused interlobular ducts isolated from guinea-pig pancreas.

@article{Ishiguro2000CO2PA,
  title={CO2 permeability and bicarbonate transport in microperfused interlobular ducts isolated from guinea-pig pancreas.},
  author={Hiroki Ishiguro and Satoru Naruse and Motoji Kitagawa and Atsushi Suzuki and Akiko Yamamoto and Tetsuo Hayakawa and R. Maynard Case and Martin C. Steward},
  journal={The Journal of physiology},
  year={2000},
  volume={528 Pt 2},
  pages={305-15}
}
Permeabilities of the luminal and basolateral membranes of pancreatic duct cells to CO2 and HCO3- were examined in interlobular duct segments isolated from guinea-pig pancreas. Intracellular pH (pHi) was measured by microfluorometry in unstimulated, microperfused ducts loaded with the pH-sensitive fluoroprobe 2'7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein (BCECF). When HCO3-/CO2 was admitted to the bath, pHi decreased transiently as a result of CO2 diffusion and then increased to a higher… CONTINUE READING

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