CO2 -dependent metabolic modulation in red blood cells stored under anaerobic conditions.

@article{Dumont2016CO2M,
  title={CO2 -dependent metabolic modulation in red blood cells stored under anaerobic conditions.},
  author={Larry J. Dumont and Angelo D'Alessandro and Zbigniew M Szczepiorkowski and Tatsuro Yoshida},
  journal={Transfusion},
  year={2016},
  volume={56 2},
  pages={392-403}
}
BACKGROUND Anaerobic red blood cell (RBC) storage reduces oxidative damage, maintains adenosine triphosphate (ATP) and 2,3-diphosphoglycerate (DPG) levels, and has superior 24-hour recovery at 6 weeks compared to standard storage. This study will determine if removal of CO2 during O2 depletion by gas exchange may affect RBCs during anaerobic storage. STUDY DESIGN AND METHODS This is a matched three-arm study (n = 14): control, O2 and CO2 depleted with Ar (AN), and O2 depleted with 95%Ar/5%CO2… CONTINUE READING

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