CO2 bubbling-based 'Nanobomb' System for Targetedly Suppressing Panc-1 Pancreatic Tumor via Low Intensity Ultrasound-activated Inertial Cavitation

@inproceedings{Zhang2015CO2B,
  title={CO2 bubbling-based 'Nanobomb' System for Targetedly Suppressing Panc-1 Pancreatic Tumor via Low Intensity Ultrasound-activated Inertial Cavitation},
  author={Kun Zhang and Huixiong Xu and Hangrong Chen and Xiaoqing Jia and Shuguang Zheng and Xiaojun Cai and Ronghui Wang and Juan Mou and Yuanyi Zheng and Jianlin Shi},
  booktitle={Theranostics},
  year={2015}
}
Noninvasive and targeted physical treatment is still desirable especially for those cancerous patients. Herein, we develop a new physical treatment protocol by employing CO2 bubbling-based 'nanobomb' system consisting of low-intensity ultrasound (1.0 W/cm(2)) and a well-constructed pH/temperature dual-responsive CO2 release system. Depending on the temperature elevation caused by exogenous low-intensity therapeutic ultrasound irradiation and the low pH caused by the endogenous acidic… CONTINUE READING
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