CO2/HCO3(-)- and calcium-regulated soluble adenylyl cyclase as a physiological ATP sensor.

  title={CO2/HCO3(-)- and calcium-regulated soluble adenylyl cyclase as a physiological ATP sensor.},
  author={Jonathan Hale Zippin and Yan-qiu Chen and Susanne G Straub and Kenneth C. Hess and Ana R. Diaz and Dana Lee and Patrick Tso and George G. Holz and Geoffrey W. G. Sharp and Lonny R. Levin and Jochen Buck},
  journal={The Journal of biological chemistry},
  volume={288 46},
The second messenger molecule cAMP is integral for many physiological processes. In mammalian cells, cAMP can be generated from hormone- and G protein-regulated transmembrane adenylyl cyclases or via the widely expressed and structurally and biochemically distinct enzyme soluble adenylyl cyclase (sAC). sAC activity is uniquely stimulated by bicarbonate ions, and in cells, sAC functions as a physiological carbon dioxide, bicarbonate, and pH sensor. sAC activity is also stimulated by calcium, and… CONTINUE READING


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