CO-MP4, a polyethylene glycol-conjugated haemoglobin derivative and carbon monoxide carrier that reduces myocardial infarct size in rats.

@article{Vandegriff2008COMP4AP,
  title={CO-MP4, a polyethylene glycol-conjugated haemoglobin derivative and carbon monoxide carrier that reduces myocardial infarct size in rats.},
  author={Kim D. Vandegriff and Mark A. Young and Jeff Lohman and Andrea Bellelli and Michele Samaja and Ashok Malavalli and Robert M. Winslow},
  journal={British journal of pharmacology},
  year={2008},
  volume={154 8},
  pages={1649-61}
}
BACKGROUND AND PURPOSE MP4 (Hemospan) is a Hb-based oxygen therapeutic agent, based on polyethylene-glycol (PEG) conjugation to Hb, undergoing clinical trials as an oxygen carrier. This study describes the functional interaction between MP4 and carbon monoxide (CO), as a CO delivery agent, and the effects of CO-MP4 on myocardial infarct size following ischaemia and reperfusion in rats. EXPERIMENTAL APPROACH Kinetic measurements of CO-MP4 binding were used to evaluate the effects of PEG… CONTINUE READING
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