CO-FISH reveals inversions associated with isochromosome formation.

  title={CO-FISH reveals inversions associated with isochromosome formation.},
  author={Susan M. Bailey and Edwin H. Goodwin and Julianne Meyne and Michael Cornforth},
  volume={11 2},
Despite the likely prevalence and documented biological impact of inverted DNA sequences in humans and other species, our ability to detect them on a routine basis is limited. The technique of chromosome orientation fluorescence in situ hybridization (CO-FISH) was used to detect obligate chromosome inversions associated with isochromosome formation in two human cell lines. Simultaneous hybridization of a strand-specific telomeric probe allowed us to deduce the absolute orientation of repetitive… CONTINUE READING

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