CO(2) homeostasis during periodic breathing in obstructive sleep apnea.

@article{Berger2000CO2HD,
  title={CO(2) homeostasis during periodic breathing in obstructive sleep apnea.},
  author={Kenneth I Berger and I Ayappa and I Barry Sorkin and Robert G. Norman and David M Rapoport and Roberta M Goldring},
  journal={Journal of applied physiology},
  year={2000},
  volume={88 1},
  pages={257-64}
}
The contribution of apnea to chronic hypercapnia in obstructive sleep apnea (OSA) has not been clarified. Using a model (D. M. Rapoport, R. G. Norman, and R. M. Goldring. J. Appl. Physiol. 75: 2302-2309, 1993), we previously illustrated failure of CO(2) homeostasis during periodic breathing resulting from temporal dissociation between ventilation and perfusion ("temporal V/Q mismatch"). This study measures acute kinetics of CO(2) during periodic breathing and addresses interapnea ventilatory… CONTINUE READING