CNV-seq, a new method to detect copy number variation using high-throughput sequencing

@article{Xie2008CNVseqAN,
  title={CNV-seq, a new method to detect copy number variation using high-throughput sequencing},
  author={Chao Xie and Martti T. Tammi},
  journal={BMC Bioinformatics},
  year={2008},
  volume={10},
  pages={80 - 80}
}
DNA copy number variation (CNV) has been recognized as an important source of genetic variation. Array comparative genomic hybridization (aCGH) is commonly used for CNV detection, but the microarray platform has a number of inherent limitations. Here, we describe a method to detect copy number variation using shotgun sequencing, CNV-seq. The method is based on a robust statistical model that describes the complete analysis procedure and allows the computation of essential confidence values for… CONTINUE READING
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