CNTF and GDNF, but not NT-4, support corticospinal motor neuron growth via direct mechanisms.

@article{Junger1998CNTFAG,
  title={CNTF and GDNF, but not NT-4, support corticospinal motor neuron growth via direct mechanisms.},
  author={Heidi Junger and Wolfgang G. Junger},
  journal={Neuroreport},
  year={1998},
  volume={9 16},
  pages={3749-54}
}
Axotomy and neurodegenerative diseases cause corticospinal motor neuron (CSMN) degeneration. We previously showed that CNTF, NT-4 and GDNF can support CSMN survival in enriched preparations. Here we developed a fluorescence-activated cell sorting method to highly purify CSMN (97+/-4.6%). We tested the neurotrophic activities of CNTF, NT-4 and GDNF on enriched and purified CSMN preparations. Similar to their effects on enriched CSMN preparations, CNTF and GDNF sustained the survival of purified… CONTINUE READING