CNTF Gene Therapy Confers Lifelong Neuroprotection in a Mouse Model of Human Retinitis Pigmentosa.

@article{Lipinski2015CNTFGT,
  title={CNTF Gene Therapy Confers Lifelong Neuroprotection in a Mouse Model of Human Retinitis Pigmentosa.},
  author={Daniel M. Lipinski and Alun R Barnard and Mandeep S Singh and Chris J. Martin and Edward K. Lee and Wayne I. L. Davies and Robert E Maclaren},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2015},
  volume={23 8},
  pages={1308-1319}
}
The long-term outcome of neuroprotection as a therapeutic strategy for preventing cell death in neurodegenerative disorders remains unknown, primarily due to slow disease progression and the inherent difficulty of assessing neuronal survival in vivo. Employing a murine model of retinal disease, we demonstrate that ciliary neurotrophic factor (CNTF) confers life-long protection against photoreceptor degeneration. Repetitive retinal imaging allowed the survival of intrinsically fluorescent cone… CONTINUE READING
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