CNS-wide Sexually Dimorphic Induction of the Major Histocompatibility Complex 1 Pathway With Aging.

@article{Mangold2017CNSwideSD,
  title={CNS-wide Sexually Dimorphic Induction of the Major Histocompatibility Complex 1 Pathway With Aging.},
  author={Colleen A. Mangold and Dustin R Masser and David R. Stanford and Georgina V. Bixler and Aditya Pisupati and Cory B. Giles and Jonathan D. Wren and Matthew M. Ford and William Edmund Sonntag and Willard M Freeman},
  journal={The journals of gerontology. Series A, Biological sciences and medical sciences},
  year={2017},
  volume={72 1},
  pages={
          16-29
        }
}
The major histocompatibility complex I (MHCI) pathway, which canonically functions in innate immune viral antigen presentation and detection, is functionally pleiotropic in the central nervous system (CNS). Alternative roles include developmental synapse pruning, regulation of synaptic plasticity, and inhibition of neuronal insulin signaling; all processes altered during brain aging. Upregulation of MHCI components with aging has been reported; however, no systematic examination of MHCI… CONTINUE READING
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