CNS-specific regulatory elements in brain-derived HIV-1 strains affect responses to latency-reversing agents with implications for cure strategies

@article{Gray2016CNSspecificRE,
  title={CNS-specific regulatory elements in brain-derived HIV-1 strains affect responses to latency-reversing agents with implications for cure strategies},
  author={Laurie R Gray and Daniel Cowley and Casey Welsh and H. Karen Lu and B J Brew and Sharon R. Lewin and Steve Lodewijk Wesselingh and Paul R. Gorry and Melissa J. Churchill},
  journal={Molecular Psychiatry},
  year={2016},
  volume={21},
  pages={574-584}
}
Latency-reversing agents (LRAs), including histone deacetylase inhibitors (HDACi), are being investigated as a strategy to eliminate latency in HIV-infected patients on suppressive antiretroviral therapy. The effectiveness of LRAs in activating latent infection in HIV strains derived from the central nervous system (CNS) is unknown. Here we show that CNS… CONTINUE READING