CNS prophylaxis of childhood leukemia: What are the long-term neurological, neuropsychological, and behavioral effects?

@article{Stehbens1991CNSPO,
  title={CNS prophylaxis of childhood leukemia: What are the long-term neurological, neuropsychological, and behavioral effects?},
  author={James A. Stehbens and Thomas A. Kaleita and Robert Noll and William E Maclean and Richard T. O'Brien and Mary J. Waskerwitz and George Denman Hammond},
  journal={Neuropsychology Review},
  year={1991},
  volume={2},
  pages={147-177}
}
Current medical treatments for childhood acute lymphoblastic leukemia (ALL) have improved the outlook to where more than 50% can be expected to survive five years or more. The use of CNS prophylaxis has contributed in a significant way to these improved survival statistics by reducing the likelihood of CNS relapses. The literature relating to the potential adverse psychological consequences of CNS prophylaxis, which include cranial radiation therapy (CRT), is reviewed and analyzed. The majority… CONTINUE READING

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