CNS peroxiredoxins and their regulation in health and disease.

@article{Bell2011CNSPA,
  title={CNS peroxiredoxins and their regulation in health and disease.},
  author={Karen F. S. Bell and Giles E Hardingham},
  journal={Antioxidants & redox signaling},
  year={2011},
  volume={14 8},
  pages={1467-77}
}
Oxidative stress is thought to be a contributing factor in many chronic neurodegenerative pathologies, as well as acute cerebrovascular disorders such as stroke. Peroxiredoxins are a family of antioxidant enzymes that reduce peroxides directly through the use of a redox active cysteine within their active site, which in the process becomes oxidized. In order to cycle back to the reduced state, many peroxiredoxins rely on thiol-dependent reduction by the ubiquitous antioxidant enzyme thioredoxin… CONTINUE READING

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