CNS peroxiredoxins and their regulation in health and disease.

  title={CNS peroxiredoxins and their regulation in health and disease.},
  author={Karen F. S. Bell and Giles E Hardingham},
  journal={Antioxidants & redox signaling},
  volume={14 8},
Oxidative stress is thought to be a contributing factor in many chronic neurodegenerative pathologies, as well as acute cerebrovascular disorders such as stroke. Peroxiredoxins are a family of antioxidant enzymes that reduce peroxides directly through the use of a redox active cysteine within their active site, which in the process becomes oxidized. In order to cycle back to the reduced state, many peroxiredoxins rely on thiol-dependent reduction by the ubiquitous antioxidant enzyme thioredoxin… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 32 extracted citations

Similar Papers

Loading similar papers…